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1

Genetic modulation of TLR8 response following bacterial phagocytosis

Michael P. Gantier, Aaron T. Irving, Maria Kaparakis-Liaskos, Dakang Xu, Vanessa A. Evans, Paul U. Cameron, James A. Bourne, Richard L. Ferrero, Matthias John, Mark A. Behlke, Bryan R.G. Williams

Journal:

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

2

Gene silencing by synthetic U1 Adaptors

Goraczniak, Rafal, Behlke, Mark A, Gunderson, Samuel I

Journal:

Nature Biotechnology

Year:

2009

Language:

english

File:

PDF, 533 KB

english, 2009

3

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

Marques, Joao Trindade, Devosse, Thalie, Wang, Die, Zamanian-Daryoush, Maryam, Serbinowski, Paul, Hartmann, Rune, Fujita, Takashi, Behlke, Mark A, Williams, Bryan RG

Journal:

Nature Biotechnology

Year:

2006

Language:

english

File:

PDF, 260 KB

english, 2006

4

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Isabel Nawroth, Jan Alsner, Mark A. Behlke, Flemming Besenbacher, Jens Overgaard, Kenneth A. Howard, Jørgen Kjems

Journal:

Radiotherapy and Oncology

Year:

2010

Language:

english

File:

PDF, 658 KB

english, 2010

5

A modular platform for targeted RNAi therapeutics

Kedmi, Ranit, Veiga, Nuphar, Ramishetti, Srinivas, Goldsmith, Meir, Rosenblum, Daniel, Dammes, Niels, Hazan-Halevy, Inbal, Nahary, Limor, Leviatan-Ben-Arye, Shani, Harlev, Michael, Behlke, Mark, Benha

Journal:

Nature Nanotechnology

Year:

2018

Language:

english

File:

PDF, 1.92 MB

english, 2018

6

RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers

Joseph R Dobosy, Scott D Rose, Kristin R Beltz, Susan M Rupp, Kristy M Powers, Mark A Behlke, Joseph A Walder

Journal:

BMC Biotechnology

Year:

2011

Language:

english

File:

PDF, 769 KB

english, 2011

7

Identification of T-cell receptorVβdeletion mutant mouse strain AU/ssJ (H-2q) which is resistant to collagen-induced arthritis

Tariq M. Haqqi, Subhashis Banerjee, Wendy L. Jones, Gary Anderson, Mark A. Behlke, Dennis Y. Loh, Harvinder S. Luthra, Chella S. David

Journal:

Year:

1989

Language:

english

File:

PDF, 542 KB

english, 1989

8

T-cell receptorVTβgenes in natural populations of mice

Konrad E. Huppi, Lawrence A. D'Hoostelaere, Beverly A. Mock, Evelyne Jouvin-Marchel, Mark A. Behlke, Hubert S. Chou, R. J. Berry, Dennis Y. Loh

Journal:

Year:

1988

Language:

english

File:

PDF, 661 KB

english, 1988

9

A Direct Comparison of Anti-microRNA Oligonucleotide Potency

Kim A. Lennox, Mark A. Behlke

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 815 KB

english, 2010

10

Alternative splicing of murine T-cell receptor β-chain transcripts

Behlke, Mark A., Loh, Dennis Y.

Journal:

Year:

1986

File:

PDF, 483 KB

1986

11

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

Melkman-Zehavi, Tal, Oren, Roni, Kredo-Russo, Sharon, Shapira, Tirosh, Mandelbaum, Amitai D, Rivkin, Natalia, Nir, Tomer, Lennox, Kim A, Behlke, Mark A, Dor, Yuval

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 1.38 MB

english, 2011

12

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

Kim, Dong-Ho, Behlke, Mark A, Rose, Scott D, Chang, Mi-Sook, Choi, Sangdun, Rossi, John J

Journal:

Nature Biotechnology

Year:

2004

Language:

english

File:

PDF, 213 KB

english, 2004

13

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

Robbins, Marjorie A, Li, Mingjie, Leung, Irene, Li, Haitang, Boyer, Doris V, Song, Yong, Behlke, Mark A, Rossi, John J

Journal:

Nature Biotechnology

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

14

Optimizing knockdown of gene expression using the TriFECTa™ Dicer-substrate RNAi reagent system

Rose, Scott D, Collingwood, Michael A, Behlke, Mark A

Journal:

Year:

2006

Language:

english

File:

PDF, 239 KB

english, 2006

15

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA

Amarzguioui, Mohammed, Lundberg, Patric, Cantin, Edouard, Hagstrom, James, Behlke, Mark A, Rossi, John J

Journal:

Nature Protocols

Year:

2006

Language:

english

File:

PDF, 398 KB

english, 2006

16

Progress Toward In Vivo Use of siRNAs-II

Rettig, Garrett R, Behlke, Mark A

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 368 KB

english, 2011

17

Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA

NaJung Kim, Dahai Jiang, Ashley M. Jacobi, Kim A. Lennox, Scott D. Rose, Mark A. Behlke, Aliasger K. Salem

Journal:

International Journal of Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 1.64 MB

english, 2012

18

T-cell activation is enhanced by targeting IL-10 in toll-like receptor stimulated macrophages

Ryan McMahon Walk, Felix C. Blanco, Jason A. Snyder, Steven Elliott, Ashley M. Jacobi, Mark A. Behlke, Stanislav Vukmanovic, Anthony Sandler

Journal:

Journal of the American College of Surgeons

Year:

2011

Language:

english

File:

PDF, 49 KB

english, 2011

19

Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo

Patric Lundberg, Hui-Jung Yang, Seung-Jae Jung, Mark A. Behlke, Scott D. Rose, Edouard M. Cantin

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 859 KB

english, 2012

20

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction

Murali Ramaswamy, Lei Shi, Steven M. Varga, Sailen Barik, Mark A. Behlke, Dwight C. Look

Journal:

Year:

2006

Language:

english

File:

PDF, 545 KB

english, 2006

21

Corrigendum to “Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction” [Virology 344 (2006) 328–339]

Murali Ramaswamy, Lei Shi, Steven M. Varga, Sailen Barik, Mark A. Behlke, Dwight C. Look

Journal:

Year:

2007

Language:

english

File:

PDF, 72 KB

english, 2007

22

Evidence That the SRY Protein Is Encoded by a Single Exon on the Human Y Chromosome

Mark A. Behlke, Jonathan S. Bogan, Peggy Beer-Romero, David C. Page

Journal:

Year:

1993

File:

PDF, 276 KB

1993

23

Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability

Bernardo G. Moreira, Yong You, Mark A. Behlke, Richard Owczarzy

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 211 KB

english, 2005

24

miR-302b maintains “stemness” of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression

Nan Sook Lee, Jong Soo Kim, Wha Ja Cho, Man Ryul Lee, Riley Steiner, Andrea Gompers, Daijun Ling, Jae Zhang, Pl Strom, Mark Behlke, Sung-Hwan Moon, Paul M. Salvaterra, Richard Jove, Kye-Seong Kim

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 690 KB

english, 2008

25

Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress

Carlos I. Michel, Christopher L. Holley, Benjamin S. Scruggs, Rohini Sidhu, Rita T. Brookheart, Laura L. Listenberger, Mark A. Behlke, Daniel S. Ory, Jean E. Schaffer

Journal:

Cell Metabolism

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

26

CS3-4 Characterisation of microRNA turnover reveals sustained modulation of innate immunity

Michael P. Gantier, Claire E. McCoy, Mark A. Behlke, Bryan R.G. Williams

Journal:

Year:

2010

Language:

english

File:

PDF, 134 KB

english, 2010

27

Development of an siRNA delivery system targeting macrophage function in-vivo

Felix C. Blanco, Priya Srinivasan, Ryan M. Walk, Jason A. Snyder, Mark Behlke, Aliasger K. Salem, Stanislav Vukmanovic, Anthony D. Sandler

Journal:

Journal of the American College of Surgeons

Year:

2012

Language:

english

File:

PDF, 58 KB

english, 2012

28

Altered Purkinje cell miRNA expression and SCA1 pathogenesis

Rodriguez-Lebron, Edgardo, Liu, Gumei, Keiser, Megan, Behlke, Mark A., Davidson, Beverly L.

Journal:

Neurobiology of Disease

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

29

Effects of Sodium Ions on DNA Duplex Oligomers: Improved Predictions of Melting Temperatures

Owczarzy, Richard, You, Yong, Moreira, Bernardo G., Manthey, Jeffrey A., Huang, Lingyan, Behlke, Mark A., Walder, Joseph A.

Journal:

Year:

2004

Language:

english

File:

PDF, 429 KB

english, 2004

30

Predicting Stability of DNA Duplexes in Solutions Containing Magnesium and Monovalent Cations

Owczarzy, Richard, Moreira, Bernardo G., You, Yong, Behlke, Mark A., Walder, Joseph A.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.33 MB

english, 2008

31

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

Lennox, Kim A, Owczarzy, Richard, Thomas, Derek M, Walder, Joseph A, Behlke, Mark A

Journal:

Molecular Therapy — Nucleic Acids

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

32

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

Howard, Kenneth A, Paludan, Søren R, Behlke, Mark A, Besenbacher, Flemming, Deleuran, Bent, Kjems, Jørgen

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 1.45 MB

english, 2009

33

Tandem Linkage and Unusual RNA Splicing of the T-Cell Receptor β -Chain Variable-Region Genes

Hubert S. Chou, Steven J. Anderson, Marjorie C. Louie, Sandip A. Godambe, Maria Rosa Pozzi, Mark A. Behlke, Konrad Huppi and Dennis Y. Loh

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 1.11 MB

english, 1987

34

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

Khairuddin, Norliana, Gantier, Michael P, Blake, Stephen J, Wu, Sherry Y, Behlke, Mark A, Williams, Bryan RG, McMillan, Nigel AJ

Journal:

Immunology & Cell Biology

Year:

2012

Language:

english

File:

PDF, 512 KB

english, 2012

35

Post-Transcriptional Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Expression and Function by MicroRNAs

Ramachandran, Shyam, Karp, Philip H., Osterhaus, Samantha R., Jiang, Peng, Wohlford-Lenane, Christine, Lennox, Kim A., Jacobi, Ashley M., Praekh, Kal, Rose, Scott D., Behlke, Mark A., Xing, Yi, Welsh,

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

36

Nucleotide Bias Observed with a Short SELEX RNA Aptamer Library

Thiel, William H., Bair, Thomas, Wyatt Thiel, Kristina, Dassie, Justin P., Rockey, William M., Howell, Craig A., Liu, Xiuying Y., Dupuy, Adam J., Huang, Lingyan, Owczarzy, Richard, Behlke, Mark A., Mc

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2011

Language:

english

File:

PDF, 785 KB

english, 2011

37

Spectroscopic Features of Dual Fluorescence/Luminescence Resonance Energy-Transfer Molecular Beacons

Tsourkas, Andrew, Behlke, Mark A., Xu, Yangqing, Bao, Gang

Journal:

Analytical Chemistry

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

38

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe

Hernandez, Frank J, Huang, Lingyan, Olson, Michael E, Powers, Kristy M, Hernandez, Luiza I, Meyerholz, David K, Thedens, Daniel R, Behlke, Mark A, Horswill, Alexander R, McNamara, James O

Journal:

Nature Medicine

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

39

Assessing the Sensitivity of Commercially Available Fluorophores to the Intracellular Environment

Chen, Antony K., Cheng, Zhiliang, Behlke, Mark A., Tsourkas, Andrew

Journal:

Analytical Chemistry

Year:

2008

Language:

english

File:

PDF, 468 KB

english, 2008

40

Chemical Modification of siRNAs for In Vivo Use

Behlke, Mark A.

Journal:

Oligonucleotides

Year:

2008

Language:

english

File:

PDF, 359 KB

english, 2008

41

Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs

Collingwood, Michael A., Rose, Scott D., Huang, Lingyan, Hillier, Chris, Amarzguioui, Mohammad, Wiiger, Merete T., Soifer, Harris S., Rossi, John J., Behlke, Mark A.

Journal:

Oligonucleotides

Year:

2008

Language:

english

File:

PDF, 862 KB

english, 2008

42

In vivo SELEX for Identification of Brain-penetrating Aptamers

Cheng, Congsheng, Chen, Yong Hong, Lennox, Kim A, Behlke, Mark A, Davidson, Beverly L

Journal:

Molecular Therapy — Nucleic Acids

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

43

Optimal Lipofection Reagent Varies with the Molecular Modifications of the DNA

CONRAD, ABIGAIL H., BEHLKE, MARK A., JAFFREDO, THIERRY, CONRAD, GARY W.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1998

Language:

english

File:

PDF, 3.60 MB

english, 1998

44

Degradation of Nuclease-Stabilized RNA Oligonucleotides in Mycoplasma-Contaminated Cell Culture Media

Hernandez, Frank J., Stockdale, Katie R., Huang, Lingyan, Horswill, Alexander R., Behlke, Mark A., McNamara, James O.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2012

Language:

english

File:

PDF, 568 KB

english, 2012

45

Determinants of Cytokine Induction by Small Interfering RNA in Human Peripheral Blood Mononuclear Cells

Zamanian-Daryoush, Maryam, Marques, Joao T., Gantier, Michael P., Behlke, Mark A., John, Matthias, Rayman, Patricia, Finke, James, Williams, Bryan R.G.

Journal:

Journal of Interferon & Cytokine Research

Year:

2008

Language:

english

File:

PDF, 1.95 MB

english, 2008

46

780. Inhibition of Respiratory Syncytial Virus Gene Expression and Replication by 27mer Dicer Substrate siRNAs

Fischer, Anthony J., Wohlford-Lenane, Christine L., Rose, Scott D., Varga, Steven M., Behlke, Mark A., McCray, Paul B.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

47

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia

Krishnamurthy, Sateesh, Behlke, Mark A, Apicella, Michael A, McCray, Paul B, Davidson, Beverly L

Journal:

Molecular Therapy — Nucleic Acids

Year:

2014

Language:

english

File:

PDF, 695 KB

english, 2014

48

U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo

Goraczniak, Rafal, Wall, Brian A, Behlke, Mark A, Lennox, Kim A, Ho, Eric S, Zaphiros, Nikolas H, Jakubowski, Christopher, Patel, Neil R, Zhao, Steven, Magaway, Carlo, Subbie, Stacey A, Jenny Yu, Lume

Journal:

Molecular Therapy — Nucleic Acids

Year:

2013

Language:

english

File:

PDF, 4.03 MB

english, 2013

49

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides

Hammond, Suzan M, McClorey, Graham, Nordin, Joel Z, Godfrey, Caroline, Stenler, Sofia, Lennox, Kim A, Smith, CI Edvard, Jacobi, Ashley M, Varela, Miguel A, Lee, Yi, Behlke, Mark A, Wood, Matthew J A,

Journal:

Molecular Therapy — Nucleic Acids

Year:

2014

Language:

english

File:

PDF, 1.43 MB

english, 2014

50

Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia

Krishnamurthy, Sateesh, Behlke, Mark A, Ramachandran, Shyam, Salem, Aliasger K, McCray Jr, Paul B, Davidson, Beverly L

Journal:

Molecular Therapy — Nucleic Acids

Year:

2012

Language:

english

File:

PDF, 2.56 MB

english, 2012

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